Beta-Caryophyllene a dietary cannabinoid

 

CARYOPHYLLENE EFFECTS ON CANNABINOID RECEPTORS

β-caryophyllene terpenes Australia is commonly ingested with vegetable foods, particularly black pepper. Accordingly, adequate daily intake of caryophyllene could potentially modulate inflammatory and other pathophysiological processes via the endocannabinoid system and help maintain health. The potential of β-caryophyllene in both human and animal health needs further investigation as much of the focus of cannabinoids has been on cannabis and cannabidiol, CBD. As a selective agonist of cannabinoid receptor type-2 (CB2), caryophyllene has been shown to exert significant cannabi-mimetic anti-inflammatory effects. Anti-nociceptive, neuroprotective, anxiolytic, antidepressant, and anti-alcoholism activities have also been reported in vitro and in rodent studies.

β-Caryophyllene terpenes has the distinction of being the first known “dietary cannabinoid,” a common component of food that has GRAS (Generally Recognized as Safe) status and is approved by the FDA for food use. β-Caryophyllene is the primary sesquiterpene contributing to the spiciness of black pepper; it is also a major constituent of cloves, hops, rosemary, copaiba, and cannabis.

CB1 is responsible for the psychoactive effects associated with certain cannabinoids such as THC. However, CB2, particularly in peripheral tissues in the body, is a therapeutic target for treatment of inflammation, pain, atherosclerosis, and osteoporosis (Gertsch, 2008; Gertsch et al., 2008). β-Caryophyllene has now been shown to be directly beneficial for: 

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